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KMID : 0848120210460010007
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International Journal of Oral Biology
2021 Volume.46 No. 1 p.7 ~ p.14
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Vinpocetine inhibits the proliferation and induces apoptosis in human colon cancer cells
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Kim Mi-Kyoung
Park Hyun-Joo
Kim Yeon
Kim Yong-Il
Bae Soo-Kyung
Kim Hyung-Joon
Bae Moon-Kyoung
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Abstract
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Vinpocetine induces anti-inflammatory effects in various inflammatory diseases via the inhibition of phosphodiesterase type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the effect of vinpocetine on the proliferation of colon cancer cells and its underlying molecular mechanisms. Our data showed that vinpocetine inhibits the viability and proliferation of colon cancer cells. Vinpocetine treatment induced cell death in HCT116 cells, which the percentages of sub-G1 phase were significantly increased, and the apoptosis-related genes were regulated after HCT116 cells were treated with vinpocetine. In sum, our findings indicated that vinpocetine could be a therapeutically useful candidate in the treatment of colon cancer.
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KEYWORD
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Vinpocetine, Colon cancer cells, Apoptosis, Proliferation
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